The table below provides categories of formulas for premature and term infants. Formulas within each category are comparable and safe to substitute for each other, in case of shortages. Any substitution should only be done under the recommendation and supervision of a healthcare professional.
Please be aware that formula mixing instructions, including proper ratios of powder to water, can vary significantly. Follow all mixing instructions on the container. Use the specific scoop that comes with each can.
NASPGHAN does not endorse any specific formulas, nor the general use of formula over possible use of human milk as the optimal source of infant nutrition.
COMPARABLE FORMULAS THAT ARE SAFE TO INTERCHANGE (In alphabetical order by label)
Alfamino Infant (Nestlé)
Elecare Infant (Abbott)
Neocate Infant (Nutricia)
Neocate Syneo* (Nutricia)
Puramino DHA & ARA infant (Mead Johnson)
*Contains probiotics, use with caution if infant is immunosuppressed or has a central line
COMPARABLE FORMULAS THAT ARE SAFE TO INTERCHANGE (In alphabetical order by label)
Alimentum Infant (Abbott)
Alimentum Ready to Feed (Abbott)
Extensive HA Infant (Nestle)
Good Start Extensive HA Infant (Gerber)
Nutramigen Infant (Mead Johnson)
Nutrimagen Ready to Feed (Mead Johnson)
Pepticate (Nutricia) (contains lactose)
Pregestemil (Mead Johnson)
Private Label Hypoallergenic or Extensively Hydrolyzed (Perrigo)#
#Private Label/Store brand formulas are available at many retail outlets and will have a variety of names. Retail outlets include but are not limited to: Aldi, Amazon, Costco CVS, HEB, Kroger, Meijer, Safeway, Sam’s Club, Target, Topco, Walgreens, and Walmart.
COMPARABLE FORMULAS THAT ARE SAFE TO INTERCHANGE (In alphabetical order by label)
Enfamil Prosobee (Mead Johnson)
Good Start Soy (Gerber)
Similac Soy Isomil Infant (Abbott)
Private Label Soy (Perrigo)#
#Private Label/Store brand formulas are available at many retail outlets and will have a variety of names. Retail outlets include but are not limited to: Aldi, Amazon, Costco CVS, HEB, Kroger, Meijer, Safeway, Sam’s Club, Target, Topco, Walgreens, and Walmart.
COMPARABLE FORMULAS THAT ARE SAFE TO INTERCHANGE (In alphabetical order by label) Calories per ounce can vary
Enfamil Premature (Mead Johnson)
Enfamil NeuroPro Enfacare (Mead Johnson)
Enfamil NeuroPro Enfacare Premature Discharge Liquid (Mead Johnson)
Similac Expert Care Neosure Powder (Abbott)
Similac Expert Care Neosure Ready to Feed (Abbott)
Similac Neosure Infant (Abbott)
Similac Neosure Optigrow (Abbott)
Similac Neosure (Abbott)
Similac Neosure Ready to Use (Abbott)
Similac Special Care Ready to Feed (Abbott)
COMPARABLE FORMULAS THAT ARE SAFE TO INTERCHANGE (In alphabetical order by label)
A2 Platinum Infant (A2)
Baby’s Only Organic (Nature’s One)
Bobbie Organic Infant formula (Bobbie/Perrigo)
Bubs Essential Infant (Bubs)
Bubs 365 Day Grass Fed Infant Formula (Bubs)
Burt’s Bees Baby Powder Milk Based Formula* (Perrigo)
ByHeart Whole Nutrition Infant Formula (ByHeart)
Earth’s Best Organic (Earth’s Best/Perrigo)
Earth’s Best Organic Gentle (Earth’s Best/Perrigo)
Earth’s Best Organic Sensitivity (Earth’s Best/Perrigo)
Enfamil A2 (Mead Johnson)
Enfamil AR (not for infants with rice allergy) (Mead Johnson)
Enfamil Concentrated Liquid (Mead Johnson)
Enfamil Infant Neuropro (Mead Johnson)
Enfamil Gentlease Powder (Mead Johnson)
Enfamil Gentlease Ready to Feed ( Mead Johnson)
Enfamil Liquid Baby Formula ( Mead Johnson)
Enfamil NeuroPro Gentlease Powder ( Mead Johnson)
Enfamil NeuroPro Gentlease Ready to Feed ( Mead Johnson)
Enfamil NeuroPro Powder ( Mead Johnson)
Enfamil NeuroPro Ready to Feed ( Mead Johnson)
Enfamil Optimum ( Mead Johnson)
Enfamil Reguline ( Mead Johnson)
Enfamil Simply Organic ( Mead Johnson)
Good Start DHA & ARA (Gerber)
Good Start Gentle Pro(Gerber)*
Good Start Sooth Pro (Gerber)*
Happy Baby Organic Infant Formula Stage 1 (Happy Baby) (Stage 2 formula is not appropriate for children <6 months of age)
Happy Baby Organic Infant Formula Stage 1 A2 (Happy Baby)
J&J Sunrise Milk-Based Infant Formula with Iron DHA & ARA (J&J)
Kendamil Classic Infant Formula Milk Based Powder with Iron (Kendamil)
Kendamil Organic Infant Formula Milk Based Powder with Iron (Kendamil)
Nestle Nan OptiPro 1 Infant Formula with Iron (Nestle)
Nestle Nan Pro Infant Formula (Nestle)*
Nutricia Fortini Infant Formula (Nutricia) (30 kcal/oz)
Pure Bliss Infant Formula (Abbott)
Similac 360 Total Care (Abbott)
Similac 360 Total Care Ready to Feed(Abbott)
Similac 360 Total Care Advance Ready to Feed (Abbott)
Similac 360 Total Care Non-GMO Ready to Feed (Abbott)
Similac 360 Total Care Sensitive (Abbott)
Similac 360 Total Care Sensitive Ready to Feed (Abbott)
Similac Advance (Abbott)
Similac Advance Liquid Concentrate (Abbott)
Similac Advance Ready to Feed (Abbott)
Similac Advance Early Shield (Abbott)
Similac Advance Early Shield Ready to Feed (Abbott)
Similac Advance Optigrow (Abbott)
Similac Advance Optigrow Liquid Concentrate (Abbott)
Similac Pro Total Comfort (Abbott)
Similac Pro Total Comfort Ready to Feed (Abbott)
Similac Sensitive (formerly Similac Lactose-free) (Abbott)
Similac for Spit-Up (not for infants with rice allergy) (Abbott)
Westly Farms Gentle Premium (Perrigo)
Other Private Labels
Private Label Advantage (Perrigo)#
Private Label Advantage Premium (Perrigo)#
Private Label Gentle (Perrigo)#
Private Label Gentle Premium (Perrigo)#
Private Label Infant (Perrigo)#
Private Label Infant Premium (Perrigo)#
Private Label Sensitivity (Perrigo)#
Private Label Sensitivity Premium (Perrigo)#
^ Formulas in this standard formula/intact and/or partially hydrolyzed cow’s milk protein category are safe to substitute for each other. All formulas listed are FDA reviewed and meet US Government and American Academy of Pediatrics (AAP) nutritional standards, with variation in ingredients, including but not limited to macronutrients (protein, carbohydrates, and fats) and micronutrient blends, subtypes and/or added levels (vitamins and minerals).
*Contains probiotics, use with caution if infant is immunosuppressed or has a central line
#Private Label/Store brand formulas are available at many retail outlets and will have a variety of names. Retail outlets include but are not limited to: Aldi, Amazon, Costco CVS, HEB, Kroger, Meijer, Safeway, Sam’s Club, Target, Topco, Walgreens, and Walmart.
COMPARABLE FORMULAS THAT ARE SAFE TO INTERCHANGE (In alphabetical order by label)
Bubs Goat Milk Formula(Bubs)
Kabrita Goat Milk Based Infant formula (Kabrita)
~ Goat Milk intact protein formulas should be safe to interchange with cow milk intact protein formulas. Goat milk intact protein formulas should NOT be used in infants with milk protein allergy and are NOT interchangeable with either extensively hydrolyzed or amino-acid based formulas.
The information provided is intended solely for educational purposes and not as medical advice. It is not a substitute for care by a trained medical provider. NASPGHAN does not endorse any of these products and is not responsible for any omissions.
FDA Notified formulas as of March 2025
*Contains probiotics, use with caution if infant is immunosuppressed or has a central line
^ Formulas in this standard formula/intact and/or partially hydrolyzed cow’s milk protein category are safe to substitute for each other. All formulas listed are FDA reviewed and meet US Government and American Academy of Pediatrics (AAP) nutritional standards, with variation in ingredients, including but not limited to macronutrients (protein, carbohydrates, and fats) and micronutrient blends, subtypes and/or added levels (vitamins and minerals).
~ Goat Milk intact protein formulas should be safe to interchange with cow milk intact protein formulas. Goat milk intact protein formulas should NOT be used in infants with milk protein allergy and are NOT interchangeable with either extensively hydrolyzed or amino-acid based formulas.
#Private Label/Store brand formulas are available at many retail outlets and will have a variety of names. Retail outlets include but are not limited to: Aldi, Amazon, Costco CVS, HEB, Kroger, Meijer, Safeway, Sam’s Club, Target, Topco, Walgreens, and Walmart.
